Počet záznamů: 1

Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis

  1. 1.
    0348119 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Dunne, A. - Ross, P. J. - Pospíšilová, Eva - Mašín, Jiří - Meaney, A. - Sutton, C. E. - Iwakura, Y. - Tschopp, J. - Šebo, Peter - Mills, K. H. G.
    Inflammasome Activation by Adenylate Cyclase Toxin Directs Th17 Responses and Protection against Bordetella pertussis.
    Journal of Immunology. Roč. 187, č. 3 (2010), s. 1711-1719 ISSN 0022-1767
    Grant CEP: GA ČR GA310/08/0447; GA AV ČR IAA500200914
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: ADAPTIVE IMMUNE-RESPONSES * IL-17-PRODUCING T-CELLS * HOST-DEFENSE
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 5.745, rok: 2010

    In this article, we demonstrate that inflammasome-mediated IL-1b plays a critical role in promoting Ag-specific Th17 cells and in generating protective immunity against Bordetella pertussis infection. Using a murine respiratory challenge model, we demonstrated that the course of B. pertussis infection was significantly exacerbated in IL-1R type I-defective (IL-1RI2/2) mice. We found that adenylate cyclase toxin (CyaA), a key virulence factor secreted by B. pertussis, induced robust IL-1b production by dendritic cells through activation of caspase-1 and the NALP3-containing inflammasome complex. Using mutant toxins, we demonstrate that CyaA-mediated activation of caspase-1 was not dependent on adenylate cyclase enzyme activity but was dependent on the pore-forming capacity of CyaA
    Trvalý link: http://hdl.handle.net/11104/0188731