Počet záznamů: 1

Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cell receptors rNKR-P1A and hCD69

  1. 1.
    0348116 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Catelani, G. - D’Andrea, F. - Griselli, A. - Guazelli, L. - Němcová, P. - Bezouška, K. - Křenek, Karel - Křen, Vladimír
    Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cell receptors rNKR-P1A and hCD69.
    Bioorganic and Medicinal Chemistry Letters. Roč. 20, č. 15 (2010), s. 4645-4648 ISSN 0960-894X
    Grant CEP: GA MŠk OC 136; GA MŠk(CZ) LC06010
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Deoxynojirimycin * NK cells * hCD69 receptors
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 2.661, rok: 2010

    Deoxynojirimycin (1) and two new related 4-O-hexosaminyl-containing disaccharide mimics, Beta-D-Tal-NAc-(1-4)-DNJ (4) and Beta-D-ManNAc-(1-4)-DNJ (5), have been studied as agonists of natural killer (NK) cell receptors. As a positive and unexpected result, DNJ (1) displayed a remarkable activation effect towards both NKR-P1A (rat) and CD69 (human) receptors, and a quite similar activity was found for 4 and 5. The synthesis of the two disaccharide mimics is based on an approach that avoids the glycosylation step using known intermediates arising from lactose. The key stage of the synthesis involves the construction of the DNJ unit through an initial C-5 oxidation of the reducing D-glucopyranosyl unit followed by a stereoselective double-reductive aminocyclization of the 1,5-dicarbonyl disacharide intermediates
    Trvalý link: http://hdl.handle.net/11104/0188728