Počet záznamů: 1

Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons

  1. 1.
    0347670 - UEM-P 2011 RIV IE eng J - Článek v odborném periodiku
    Vacek, P. M. - Albertini, R. J. - Šrám, Radim - Upton, P. - Swenberg, J. A.
    Hemoglobin adducts in 1,3-butadiene exposed Czech workers: Female–male comparisons.
    Chemico-Biological Interactions. Roč. 188, č. 3 (2010), s. 668-676 ISSN 0009-2797
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: 3-Butadiene * metabolism * THB-Val hemoglobin adducts
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 2.832, rok: 2010

    The results of this study confirm the findings of the previous molecular epidemiological study of female and male 1,3-butadiene (BD) exposed Czech workers, showing that females appeared to absorb or metabolize less BD per unit exposure conc. that did males (based on metabolite conc. in urine). In this study, another biomarker to measure a second metabolite of BD was used. The authors measured production and accumulation of the 1,2-dihydroxy-3,4-epoxybutane (EBD) metabolite as reflected in THB-Val hemoglobin adduct concentrations. In both the control and exposed groups mean THB-Val concentrations were significantly higher for males than females. It was also found that the size of difference increased with exposure.
    Trvalý link: http://hdl.handle.net/11104/0188401