Počet záznamů: 1

An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts

  1. 1.
    0347664 - UEM-P 2011 RIV IE eng J - Článek v odborném periodiku
    Topinka, Jan - Hovorka, J. - Milcová, Alena - Schmuczerová, Jana - Kroužek, J. - Rössner ml., Pavel - Šrám, Radim
    An acellular assay to assess the genotoxicity of complex mixtures of organic pollutants bound on size segregated aerosol. Part I: DNA adducts.
    Toxicology Letters. Roč. 198, č. 1 (2010), s. 304-311 ISSN 0378-4274
    Grant CEP: GA MŠk 2B08005
    Grant ostatní: GA MŽP(CZ) SP/1A3/149/08
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: Air pollution * Complex mixtures * DNA adducts
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.581, rok: 2010

    The genotoxicity of the organic extracts (EOMs) from three size fractions of aerosols (ranging from 0.17 to 10µm and collected in 4 localities differing in the extent of pollution) was compared using the analysis of total DNA adducts induced in an acellular assay with/without metabolic activation. It was found that most of the observed genotoxicity was connected with a fine particulate matter fraction (<1µm). These fine fractions bound the highest amount of c-PAHs in all aerosol sites, which might be related to their higher specific surface. As for aerosol mass, both fine and condensational fractions are effective carriers of c-PAHs. Similarly, the DNA adduct levels per m3 of air were highest for the fine fraction and a strong correlation was found between the c-PAHs and DNA adduct levels induced by EOMs in all the localities and for various size fractions.
    Trvalý link: http://hdl.handle.net/11104/0188395