Počet záznamů: 1

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits

  1. 1.
    0347601 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Schwenk, J. - Metz, M. - Zolles, G. - Tureček, Rostislav - Fritzius, T. - Bildl, W. - Tarusawa, E. - Kulik, A. - Unger, A. - Ivankova, K. - Seddik, R. - Tiao, J. Y. - Rajalu, M. - Trojanová, Johana - Rohde, V. - Gassmann, M. - Schulte, U. - Fakler, B. - Bettler, B.
    Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits.
    Nature. Roč. 465, č. 7295 (2010), s. 231-237 ISSN 0028-0836
    Grant CEP: GA ČR GA309/06/1304
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: GABA(B) * nhibitor neurotransmitter * receptors
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 36.101, rok: 2010

    GABA(B) receptors are the G-protein-coupled receptors for GABA, the main inhibitory neurotransmitter in the brain. We show by functional proteomics that GABA(B) receptors in the brain are high-molecular-mass complexes of GABA(B1), GABA(B2) and members of a subfamily of the KCTD proteins. KCTD proteins associate tightly with the carboxy terminus of GABA(B2) as auxiliary subunits of GABA(B) receptors and determine the pharmacology and kinetics of the receptor response.
    Trvalý link: http://hdl.handle.net/11104/0188348