Počet záznamů: 1

Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility

  1. 1.
    0347490 - UEM-P 2011 RIV GB eng J - Článek v odborném periodiku
    Lascors, J. - Försti, A. - Chen, B. - Buch, S. - Steinke, V. - Rahner, N. - Holinski-Feder, E. - Morak, M. - Schackert, H. K. - Görgens, H. - Schulmann, K. - Goecke, T. - Kloor, M. - Engel, C. - Büttner, R. - Kunkel, N. - Weires, M. - Hoffmeister, M. - Pardini, Barbara - Naccarati, Alessio - Vodičková, Ludmila - Novotný, J. - Schreiber, S. - Krawczak, M. - Bröring, C. D. - Völzke, H. - Schafmayer, C. - Vodička, Pavel - Chang-Claude, J. - Brenner, H. - Burwinkel, B. - Propping, P. - Hampe, J. - Hemminki, K.
    Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility.
    Carcinogenesis. Roč. 31, č. 9 (2010), s. 1612-1619 ISSN 0143-3334
    Grant CEP: GA ČR GA310/07/1430
    Grant ostatní: EU(XE) HEALTH-F4-2007-200767
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: colorectal cancer * gene ontology * confidence interval
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.402, rok: 2010

    In this GWAs study, 10 664 genotyped single-nucleotide polymorphisms (SNPs) passed the quality control filtering in 371 German familial CRC patients and 1263 controls, and replication studies were conducted in four additional case-control sets (4915 cases and 5607 controls). We have observed that the risk of CRC increased significantly with an increasing number of risk alleles in seven genes involved in MAPK signalling events.
    Trvalý link: http://hdl.handle.net/11104/0188262