Počet záznamů: 1

Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers

  1. 1.
    0347441 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Zerzánková, Lenka - Kostrhunová, Hana - Vojtíšková, Marie - Nováková, Olga - Suchánková, T. - Lin, M. - Guo, Z. - Kašpárková, Jana - Brabec, Viktor
    Mechanistic insights into antitumor effects of new dinuclear cis PtII complexes containing aromatic linkers.
    Biochemical Pharmacology. Roč. 80, č. 3 (2010), s. 344-351 ISSN 0006-2952
    Grant CEP: GA MŠk(CZ) LC06030; GA MŠk(CZ) ME08017; GA MŠk(CZ) ME10066; GA MŠk(CZ) OC08003; GA AV ČR(CZ) IAA400040803; GA ČR(CZ) GD301/09/H004; GA ČR(CZ) GAP301/10/0598
    Grant ostatní: GA MŠk(CZ) OC09018; GA AV ČR(CZ) KAN200200651
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: DNA * platinum * cancer
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.889, rok: 2010

    The primary objective was to understand more deeply the molecular mechanism underlying different antitumor effects of dinuclear Pt-II complexes containing aromatic linkers of different length, ([cisPt( NH3)(2)Cl](2)(4,4'-methylenedianiline)}(2+) (1) and {[cis-Pt(NH3)(2)Cl](2)(alpha,alpha'-diamino-p-xylene)}(2+) (2). These complexes belong to a new generation of promising polynuclear platinum drugs resistant to decomposition by sulfur nucleophiles which hampers clinical use of bifunctional polynuclear trans Pt-II complexes hitherto tested.
    Trvalý link: http://hdl.handle.net/11104/0188216