Počet záznamů: 1

New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties

  1. 1.
    0347364 - UOCHB-X 2011 RIV PL eng J - Článek v odborném periodiku
    Sleszynska, M. - Kwiatkowska, A. - Sobolewski, D. - Wierzba, T. H. - Katarzynska, J. - Zabrocki, J. - Borovičková, Lenka - Slaninová, Jiřina - Prahl, A.
    New bradykinin B-2 receptor antagonists - influence of C-terminal segment modifications on their pharmacological properties.
    Acta Biochimica Polonica. Roč. 56, č. 4 (2009), s. 641-648 ISSN 0001-527X
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: bradykinin
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 1.262, rok: 2009

    Analogues of the bradykinin antagonist [D-Arg(0),Hyp(3),Thi(5,8),D-Phe(7)]BK having in position 7 or 8 L-pipecolic acid or L-beta(2)-isoproline or L-beta(3)-homoproline and free or acylated N-terminal amino group were synthesized and biologically evaluated (isolated rat uterus and rat blood pressure tests). The results thus support the hypothesis about the existence of different types of BK receptors in the rat uterus and blood vessels.
    Trvalý link: http://hdl.handle.net/11104/0188157