Počet záznamů: 1

Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy

  1. 1.
    0347154 - UMG-J 2011 RIV US eng J - Článek v odborném periodiku
    Králová, Jarmila - Kejík, Z. - Bříza, T. - Poučková, P. - Kral, A. - Martásek, P. - Král, V.
    Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy.
    Journal of Medicinal Chemistry. Roč. 53, č. 1 (2010), s. 128-138 ISSN 0022-2623
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: photodynamic therapy * cancer therapy * porphyrin conjugate
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.207, rok: 2010

    The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multi-functional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.
    Trvalý link: http://hdl.handle.net/11104/0187994