Počet záznamů: 1

pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly

  1. 1.
    0347038 - UMCH-V 2011 RIV US eng J - Článek v odborném periodiku
    Filippov, Sergey K. - Starovoytova, Larisa - Koňák, Čestmír - Hrubý, Martin - Macková, Hana - Karlsson, G. - Štěpánek, Petr
    pH sensitive polymer nanoparticles: effect of hydrophobicity on self-assembly.
    Langmuir. Roč. 26, č. 18 (2010), s. 14450-14457 ISSN 0743-7463
    Grant CEP: GA ČR GAP208/10/1600; GA AV ČR IAA100500501; GA ČR GPP207/10/P054; GA ČR GESON/06/E005
    Výzkumný záměr: CEZ:AV0Z40500505
    Klíčová slova: complex * hydrophobicity * surfactant
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 4.269, rok: 2010

    For the first time, we have described the detailed mechanism of the formation of pH-sensitive nanoparticles with varying pH using dynamic information from NMR, charge properties from zeta-potential, aggregation behavior from light scattering, and particle imaging using cryo-TEM. We have shown that, at basic conditions, a polymer-surfactant complex with pearl-necklace structure exists. At lower pH, globulized complexes occur due to coil-to-globule transition of a polyanion. With a further decrease of pH, the globulized complexes assemble into larger nanoparticles that are stabilized by streric repulsion of hydrophilic PEO chains of the surfactant.
    Trvalý link: http://hdl.handle.net/11104/0006003