Počet záznamů: 1
Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes
- 1.0346345 - ÚOCHB 2011 RIV US eng J - Článek v odborném periodiku
Uchman, M. - Cígler, Petr - Grüner, Bohumír - Procházka, K. - Matějíček, P.
Micelle-like nanoparticles of block copolymer poly(ethylene oxide)-block-poly(methacrylic acid) incorporating fluorescently substituted metallacarboranes designed as HIV protease inhibitor interaction probes.
Journal of Colloid and Interface Science. Roč. 348, č. 1 (2010), s. 129-136. ISSN 0021-9797. E-ISSN 1095-7103
Grant CEP: GA MŠMT LC523; GA AV ČR IAAX00320901
Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z40320502
Klíčová slova: metallacarboranes * micelles * drug delivery
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 3.068, rok: 2010
We prepared nanoparticles differing in morphology from double-hydrophilic block copolymer poly(ethylene oxide)-block-poly(methacrylic acid), PEO–PMA, and two types of fluorescein–[3-cobalt(III) bis(1,2-dicarbollide)] conjugates, GB176 and GB179, in alkaline buffer. GB176 molecule consists of fluorescein attached to the metallacarborane anion. In GB179 molecule, the fluorescein moiety connects two metallacarborane anions. The self-assembly is based on the unusual interaction of metallacarborane clusters with PEO blocks which form insoluble micellar cores. The GB176 containing nanoparticles are loose and irregular, while the GB179 ones are rigid and spherical. The micelles were studied by static and dynamic light scattering, fluorometry and atomic force microscopy. Since the metallacarborane conjugates act as potent inhibitors of HIV protease, the presented system is important from the point of view of drug delivery.
Trvalý link: http://hdl.handle.net/11104/0187398
Počet záznamů: 1