Počet záznamů: 1

HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release

  1. 1.
    0346325 - UMCH-V 2011 RIV US eng J - Článek v odborném periodiku
    Etrych, Tomáš - Šírová, Milada - Starovoytova, Larisa - Říhová, Blanka - Ulbrich, Karel
    HPMA copolymer conjugates of paclitaxel and docetaxel with pH-controlled drug release.
    MOLECULAR PHARMACEUTICS. Roč. 7, č. 4 (2010), s. 1015-1026 ISSN 1543-8384
    Grant CEP: GA MŠk 1M0505; GA AV ČR IAAX00500803
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50200510
    Klíčová slova: N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer * docetaxel * paclitaxel
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 5.400, rok: 2010

    In this paper we describe the synthesis, physicochemical characteristics and data on the biological activity of polymer prodrugs based on the anticancer drugs paclitaxel (PTX) and docetaxel (DTX) conjugated with a water-soluble N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer drug carrier. The drugs were derivatized and then attached to the polymer backbone via a spacer that is stable under physiological conditions (pH 7.4) and hydrolytically degradable in mild acidic environments (e.g., endosomes, pH similar to 5).
    Trvalý link: http://hdl.handle.net/11104/0005970