Počet záznamů: 1

The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability

  1. 1.
    0346290 - UOCHB-X 2011 RIV CZ eng J - Článek v odborném periodiku
    Elbert, Tomáš - Břehová, Petra - Holý, Antonín
    The preparation of 3-H-labeled Acyclic Nucleoside Phosphonates and Study of their Stability.
    Collection of Czechoslovak Chemical Communications. Roč. 75, č. 7 (2010), s. 757-766 ISSN 0010-0765
    Grant CEP: GA MŠk 1M0508; GA AV ČR IAA400550801
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: tritium * 3-H NMR * acyclic nucleotide analogues
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 0.853, rok: 2010

    9-(2-Phosphonomethoxyethyl)-2,6-diamino-[8-3H]purine, 9-(2-phosphonomethoxyethyl)- [8-3H]guanine and (R)- 9-(2-phosphonomethoxypropyl)-[8-3H]adenine with specific activities of 10.9 Ci/mmol, 7.9 Ci/mmol and 16 Ci/mmol, respectively, were prepared by a catalytic dehalogenation of the corresponding 8-bromo derivatives. The rate of the exchange of the tritium label on C-8 of the purine ring in title compounds with the hydrogen of water under physiological pH at 20 °C was studied using 3H NMR.
    Trvalý link: http://hdl.handle.net/11104/0187358