Počet záznamů: 1

Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering

  1. 1.
    0345865 - UMCH-V 2011 RIV GB eng J - Článek v odborném periodiku
    Studenovská, Hana - Vodička, Petr - Proks, Vladimír - Hlučilová, Jana - Motlík, Jan - Rypáček, František
    Synthetic poly(amino acid) hydrogels with incorporated cell-adhesion peptides for tissue engineering.
    Journal of Tissue Engineering and Regenerative Medicine. Roč. 4, č. 6 (2010), s. 454-463 ISSN 1932-6254
    Grant CEP: GA AV ČR KJB400500801; GA MŠk 1M0538
    Výzkumný záměr: CEZ:AV0Z40500505; CEZ:AV0Z50450515
    Klíčová slova: polyamino acid * hydrogel * porosity
    Kód oboru RIV: CD - Makromolekulární chemie
    Impakt faktor: 3.534, rok: 2010

    Preparation of soft poly(amino acid) hydrogels containing biomimetic cell-adhesive peptides was investigated. Covalently crosslinked gels were formed by radical co-polymerization of methacryloylated macromonomer poly[N5-(2-hydroxyethyl)-L-glutamine-stat-L-alanine-stat-methacryloyllysine] with 2-hydroxyethyl methacrylate (HEMA) as minor co-monomer. Hydrogels carrying biomimetic peptides were prepared by using methacryloylated peptides, such as methacryloyl-GGGRGDSG-OH and methacryloyl-GGGYIGSR-OH, as additional monomers in the polymerization mixture. While unmodified hydrogels showed very low cell adhesion, due to their highly hydrophilic nature, the incorporation of adhesive peptides significantly improved the adhesion and viability of seeded cells.
    Trvalý link: http://hdl.handle.net/11104/0005960