Počet záznamů: 1

Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension

  1. 1.
    0345854 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Líšková, Silvia - Petrová, M. - Karen, Petr - Kuneš, Jaroslav - Zicha, Josef
    Influence of calcium-dependent potassium channel blockade and nitric oxide inhibition on norepinephrine-induced contractions in two forms of genetic hypertension.
    Journal of the American Society of Hypertension. Roč. 4, č. 3 (2010), s. 128-134 ISSN 1933-1711
    Grant CEP: GA AV ČR(CZ) IAA500110902
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: potassium channels * nitric oxide * norepinephrine
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 0.931, rok: 2010

    The activation of Ca2+-dependent K+ channels (BKCa) leads to the attenuation of vascular contraction. Our study aimed to evaluate BKCa influence on norepinephrine (NE)-induced femoral artery contraction in two forms of genetic hypertension. NO-dependent attenuation of NE-induced contractions was greater in SHR than HTG or Wistar vessels, whereas large conductance Ca2+-dependent K+ channels may play a greater role in modulating vascular contraction in the severe form of hypertension
    Trvalý link: http://hdl.handle.net/11104/0187038