Počet záznamů: 1

Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase

  1. 1.
    0345303 - BFU-R 2011 RIV DE eng J - Článek v odborném periodiku
    Ondroušková, E. - Slováčková, J. - Pelková, V. - Procházková, Jiřina - Souček, Karel - Beneš, P. - Šmarda, J.
    Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase.
    Biological Chemistry. Roč. 390, č. 1 (2009), s. 49-58 ISSN 1431-6730
    Grant CEP: GA ČR(CZ) GA204/07/0834
    Grant ostatní: GA ČR(CZ) GA301/06/0036; GA AV ČR(CZ) IAA501630801
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: Bcl-2 * heavy metals * Jun N-terminal kinase
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.732, rok: 2009

    This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we demonstrate that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of Bcl-2 protein function by phosphorylation is an important part of cell responses to stress.
    Trvalý link: http://hdl.handle.net/11104/0186611