Počet záznamů: 1

Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice

  1. 1.
    0345059 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Machová, Eva - Rudajev, Vladimír - Smyčková, Helena - Koivisto, H. - Tanila, H. - Doležal, Vladimír
    Functional cholinergic damage develops with amyloid accumulation in young adult APPswe/PS1dE9 transgenic mice.
    Neurobiology of Disease. Roč. 38, č. 1 (2010), s. 27-35 ISSN 0969-9961
    Grant CEP: GA AV ČR(CZ) IAA500110703; GA MŠk(CZ) LC554
    Grant ostatní: EC(XE) 211696
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: Alzheimer´s disease * acetylcholine release * amyloid
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 5.121, rok: 2010

    We investigated the functional characteristics of pre- and postsynaptic cholinergic transmission in APPswe/PS1dE9 double transgenic mice at a young age (7-10 weeks) before the onset of amyloid plaque formation and at adult age (5-6 months) at its onset. Our results indicate that functional pre- and postsynaptic cholinergic deficits are nor present in APPswe/PS1dE9 transgenic mice before 10 weeks of age, but develop along with beta-amyloid accumulation in the brain
    Trvalý link: http://hdl.handle.net/11104/0186423