Počet záznamů: 1

High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro

  1. 1.
    0345018 - UIVT-O 2011 RIV US eng J - Článek v odborném periodiku
    Jiruška, P. - Csicsvari, J. - Powell, A.V. - Fox, J.E. - Chang, W.C. - Vreugdenhil, M. - Li, X. - Paluš, Milan - Bujan, A.F. - Dearden, R.W. - Jefferys, J. G. R.
    High-Frequency Network Activity, Global Increase in Neuronal Activity, and Synchrony Expansion Precede Epileptic Seizures in Vitro.
    Journal of Neuroscience. Roč. 30, č. 16 (2010), s. 5690-5701 ISSN 0270-6474
    Výzkumný záměr: CEZ:AV0Z10300504
    Klíčová slova: mammalian hippocampus invitro * temporal-lobe epilepsy * nonsynaptic epileptogenesis * spatiotemporal dynamics * after-discharges * pyramidal cells * oscillations * rat * calcium * slice
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 7.271, rok: 2010

    How seizures start is a major question in epilepsy research. We demonstrate the existence of a preictal state characterized by the progressive and global increase in neuronal activity associated with a widespread buildup of low-amplitude high-frequency activity (HFA) and reduction in system complexity. Transition to seizure is characterized by a rapid expansion and fusion of the neuronal populations responsible for HFA, associated with a progressive slowing of HFA, leading to a single, massive, hypersynchronous cluster generating the high-amplitude low-frequency activity of the seizure.
    Trvalý link: http://hdl.handle.net/11104/0186396