Počet záznamů: 1

Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids

  1. 1.
    0343394 - UOCHB-X 2011 RIV DE eng J - Článek v odborném periodiku
    Hocková, Dana - Dračínský, Martin - Holý, Antonín
    Synthesis and Properties of a Novel Type of Acyclic Nucleoside Phosphonates: 2-(Purin-9-yl)ethoxyphenylphosphonic Acids.
    European Journal of Organic Chemistry. -, č. 15 (2010), s. 2885-2892 ISSN 1434-193X
    Grant CEP: GA MŠk 1M0508
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: nucleotides * phosphonates * cross-coupling
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.206, rok: 2010

    A series of novel acyclic nucleoside phosphonates with a built-in arylphosphonate moiety has been prepared by a microwave-assisted cross-coupling reaction as the key step. Their cytostatic and antiviral activities were tested. The pKa values of the target ortho-, meta- and para-substituted arylphosphonates were determined by 31P NMR titration studies.
    Trvalý link: http://hdl.handle.net/11104/0185885