Počet záznamů: 1

Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells

  1. 1.
    0343255 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Zemková, Hana - Kučka, M. - Li, S. - Gonzales-Iglesias, A. E. - Tomic, M. - Stojilkovic, S. S.
    Characterization of purinergic P2X4 receptor channels expressed in anterior pituitary cells.
    American Journal of Physiology. Roč. 298, č. 3 (2010), E664-E651 ISSN 0193-1849
    Grant CEP: GA MŠk(CZ) LC554; GA ČR(CZ) GA305/07/0681
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: P2X4 receptor * ATP * pituitary
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.686, rok: 2010

    In rat anterior pituitary tissue, mRNA transcripts for the P2X4 subunit are the most abundant and the P2X4 protein is expressed. Extracellular ATP induces ivermectin-sensitive depolarizing current in a majority of thyrotropin-releasing hormone-responsive pituitary cells, and enhances prolactin release. These results indicate that lactotrophs express homomeric and/or heteromeric P2X4 receptors which facilitate hormone secretion
    Trvalý link: http://hdl.handle.net/11104/0185773