Počet záznamů: 1

Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance

  1. 1.
    0343224 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Kučka, M. - Kretschmannová, K. - Murano, T. - Wu, Ch. P. - Zemková, Hana - Ambudkar, S. V. - Stojilkovic, S. S.
    Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance.
    Molecular Pharmacology. Roč. 77, č. 2 (2010), s. 270-279 ISSN 0026-895X
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: multidrug resistance protein * cAMP * anterior pituitary
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.725, rok: 2010

    Anterior pituitary cells fire action potentials and release cyclic nucleotides both spontaneously and in response to agonist stimulation. A tetrodotoxin-resistant background Na+ conductance is critical for firing of these action potentials. In these cells, multidrug resistance proteins MRP4 and MRP5 -mediated cyclic nucleotide efflux can be rapidly determined by the background Na+ conductance
    Trvalý link: http://hdl.handle.net/11104/0185748