Počet záznamů: 1

Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides

  1. 1.
    0342975 - UOCHB-X 2011 RIV GB eng J - Článek v odborném periodiku
    Bobula, T. - Hocek, Michal - Kotora, M.
    Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides.
    Tetrahedron. Roč. 66, č. 2 (2010), s. 530-536 ISSN 0040-4020
    Grant CEP: GA MŠk 1M0508; GA AV ČR IAA400550902
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: alkynes * C-nucleosides * aryl halides * cross-coupling reactions
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.011, rok: 2010

    An improved practical protocol for the synthesis of both anomers of 1-ethynyl-2-deoxiribosides 1 was developed. The Sonogashira coupling of ethynyldeoxyribosides 1 with vatious aryl- and heteroaryl halides was carried out under various conditions. It was found that the use of copper-free coupling protocols could reduce the oxidative dimerisation in favour of arylalkynyldeoxyriboside formation.
    Trvalý link: http://hdl.handle.net/11104/0185570