Počet záznamů: 1

Novel Nucleophilic Compounds with Oxime Group as Reactivators of Paraoxon-Inhibited Cholinesterases

  1. 1.
    0342827 - UCHP-M 2011 RIV US eng J - Článek v odborném periodiku
    Musilová, L. - Jun, D. - Paleček, J. - Církva, Vladimír - Musílek, K. - Paar, M. - Hrabinová, M. - Pohanka, M. - Kuca, K.
    Novel Nucleophilic Compounds with Oxime Group as Reactivators of Paraoxon-Inhibited Cholinesterases.
    Letters in Drug Design & Discovery. Roč. 7, č. 4 (2010), s. 260-264 ISSN 1570-1808
    Grant ostatní: GA MO(CZ) OVUOFVZ200902
    Výzkumný záměr: CEZ:AV0Z40720504
    Klíčová slova: acetylcholinesterase * butyrylcholinesterase * nerve agent
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 0.668, rok: 2010

    New cholinesterase reactivators are synthesized as potential antidotes for treatment of organophosphorus agent poisonings or as part of pseudo catalytic scavengers for improvement of the nerve agent prophylaxis. In this study, three novel potential cholinesterase reactivators (K064 - (E)-1-(pyridinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide; K065 - (E)-1-(quinolinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide; K066 - (E)-1-(isoquinolinium)-4-(2-hydroxyiminomethylpyridinium)-but-2-ene dibromide) were synthesized and tested for their potency to reactivate acetylcholinesterase (AChE, EC 3.1.1.3) and butyrylcholinesterase (BChE, 3.1.1.8) inhibited by pesticide paraoxon. As resulted, none from the synthesized compounds surpassed currently clinically used reactivators (pralidoxime, obidoxime and HI-6).
    Trvalý link: http://hdl.handle.net/11104/0185451