Počet záznamů: 1

Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet

  1. 1.
    0342535 - UOCHB-X 2011 RIV DE eng J - Článek v odborném periodiku
    Matyšková, Resha - Železná, Blanka - Maixnerová, Jana - Koutová, Darja - Haluzík, M. - Maletínská, Lenka
    Estradiol Supplementation Helps Overcome Central Leptin Resistance of Ovariectomized Mice on a High Fat Diet.
    Hormone and Metabolic Research. Roč. 42, č. 3 (2010), s. 182-186 ISSN 0018-5043
    Grant CEP: GA ČR GA305/06/0427; GA ČR GA303/09/0744
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: leptin * estrogen deficiency * obesity
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.414, rok: 2010

    Ovariectomized mice on a high fat diet represent a model of diet-induced obesity during estrogen deficiency. Ovariectomized mice on a high fat diet developed extreme obesity and hyperleptinemia and moderate hyperinsulinemia compared to those on a standard diet. The response to centrally injected leptin in ovariectomized mice on a high fat diet was insignificant, whereas in 17beta-estradiol-3-benzoate-supplemented mice, the effect was significant, particularly with respect to body weight.
    Trvalý link: http://hdl.handle.net/11104/0185248