Počet záznamů: 1

SUV39h- and Q1 A-type lamin-dependent telomere nuclear rearrangement

  1. 1.
    0342533 - BFU-R 2011 RIV US eng J - Článek v odborném periodiku
    Uhlířová, Radka - Harničarová, Andrea - Galiová-Šustáčková, Gabriela - Legartová, Soňa - Matula, Pavel - Fojtová, Miloslava - Vařecha, M. - Amrichová, J. - Vondráček, Jan - Kozubek, Stanislav - Bártová, Eva
    SUV39h- and Q1 A-type lamin-dependent telomere nuclear rearrangement.
    Journal of Cellular Biochemistry. Roč. 109, č. 5 (2010), s. 915-926 ISSN 0730-2312
    Grant CEP: GA MŠk ME 919
    Grant ostatní: GA MŠk(CZ) LC06027; GA MŠk(CZ) LC535
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: SUV39h * histone methyltransferases * telomeres
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.122, rok: 2010

    We have observed that histone hyperacetylation cause changes in radial distribution of telomeres. In the cells with abrogated expression of SUV39h and LMNA genes, we observed changes in association between telomeres and PML bodies. This structural features represents an important marker of tumor cells. Our results showed that SUV39h and A-type lamins play an important role in nuclear architecture of telomeres.
    Trvalý link: http://hdl.handle.net/11104/0185246