Počet záznamů: 1

Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency

  1. 1.
    0342427 - UOCHB-X 2011 RIV AT eng J - Článek v odborném periodiku
    Hlaváček, Jan - Pícha, Jan - Vaněk, Václav - Jiráček, Jiří - Slaninová, Jiřina - Fučík, Vladimír - Buděšínský, Miloš - Gilner, D. - Holz, R. C.
    Inhibitors of N (alpha)-acetyl-L-ornithine deacetylase: synthesis, characterization and analysis of their inhibitory potency.
    Amino Acids. Roč. 38, č. 4 (2010), s. 1155-1164 ISSN 0939-4451
    Grant CEP: GA AV ČR IAA400550614
    Grant ostatní: NSF(US) CHE-0652981
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: ArgE inhibitors * acetylornithine derivatives * synthesis * inhibitory and antiviral activity
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.106, rok: 2010

    A series of Nα-acyl(alkyl) and N (alpha)-alkoxycarbonyl-derivatives of L- and D-ornithine were prepared, characterized and analyzed for their potency toward the bacterial enzyme N (alpha)-acetyl-L-ornithine deacetylase. N (alpha)-chloroacetyl-L-ornithine was the best inhibitor tested providing an IC50 value of 85 (mu)M.
    Trvalý link: http://hdl.handle.net/11104/0185167