Počet záznamů: 1

IRESite - a Tool for The Examination of Viral and Cellular Internal Ribosome Entry Sites

  1. 1.
    0340720 - UIVT-O 2010 RIV GB eng J - Článek v odborném periodiku
    Mokrejš, M. - Mašek, T. - Vopálenský, V. - Hlubuček, P. - Delbos, P. - Pospíšek, Martin
    IRESite - a Tool for The Examination of Viral and Cellular Internal Ribosome Entry Sites.
    Nucleic Acids Research. Roč. 38, DB Issue (2010), D131-D136 ISSN 0305-1048
    Grant CEP: GA MŠk(CZ) 1M06014
    Grant ostatní: GA MŠk(CZ) LC06066; GA ČR(CZ) GA301/07/0607
    Klíčová slova: IRESite * IRES * translation * virus * database
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 7.836, rok: 2010

    The IRESite presents curated experimental evidence of many eukaryotic viral and cellular internal ribosome entry site (IRES) regions. The IRESite stores > 600 records and gradually evolved into a robust tool providing (i) biologically meaningful information regarding the IRESs and their experimental background as well as (ii) thorough concluding remarks to stored database entries and regularly updated evaluation of the reported IRES function. A substantial portion of the IRESite data results purely from in-house bioinformatic analyses of currently available sequences, in silico attempts to repeat published cloning experiments, DNA sequencing and restriction endonuclease verification of received plasmid DNA. IRESite contains a newly implemented tool for displaying RNA secondary structures and for searching through the structures currently stored in the database. The supplementary material contains an updated list of reported IRESs.
    Trvalý link: http://hdl.handle.net/11104/0183907