Počet záznamů: 1

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha

  1. 1.
    0340698 - BFU-R 2010 RIV GB eng J - Článek v odborném periodiku
    Štros, Michal - Muselíková Polanská, Eva - Štruncová, S. - Pospíšilová, Š.
    HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
    Nucleic Acids Research. Roč. 37, č. 7 (2009), s. 2070-2086 ISSN 0305-1048
    Grant CEP: GA AV ČR(CZ) IAA400040702
    Grant ostatní: GA MZd(CZ) NR9293
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: HMGB * topoisomerase IIalpha * cellular expression
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 7.479, rok: 2009

    We have demonstrated that HMGB1, but not a mutant of HMGB1 incapable of DNA bending, up-regulated the activity of the topo IIalpha promoter in human cells that lack functional retinoblastoma protein pRb. Our experiments suggested a mechanism of up-regulation of cellular expression of topo IIalpha by HMGB1/2 in pRb-negative cells by modulation of binding of transcription factor NF-Y to the topo IIalpha promoter.
    Trvalý link: http://hdl.handle.net/11104/0183888