Počet záznamů: 1

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells

  1. 1.
    0340647 - BFU-R 2010 RIV GB eng J - Článek v odborném periodiku
    Jendželovský, R. - Mikeš, J. - Koval, J. - Souček, Karel - Procházková, Jiřina - Kello, M. - Sačková, V. - Hofmanová, Jiřina - Kozubík, Alois - Fedoročko, P.
    Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.
    Photochemical & Photobiological Sciences. Roč. 8, č. 12 (2009), s. 1716-1723 ISSN 1474-905X
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: hypericin * photodynamic therapy * ABC transporters
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 2.708, rok: 2009

    We have investigated the efficiency of a combined modality approach employing 24 h pretreatment of relatively PDT-resistant HT-29 colon adenocarcinoma cells with proadifen followed by HY-PDT. Since significant accumulation of hypericin was found to be a principal factor responsible for ROS induction and therefore higher efficiency of HY-PDT, involvement of ABC transporter system was evaluated.
    Trvalý link: http://hdl.handle.net/11104/0183851