Počet záznamů: 1

Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory kapacity

  1. 1.
    0339393 - FGU-C 2010 RIV GB eng J - Článek v odborném periodiku
    Bellance, N. - Benard, G. - Furt, F. - Begueret, H. - Smolková, Katarína - Passerieux, E. - Delage, J.P. - Baste, J.M. - Moreau, P. - Rossignol, R.
    Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory kapacity.
    International Journal of Biochemistry and Cell Biology. Roč. 41, č. 12 (2009), s. 2566-2577 ISSN 1357-2725
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: tumors * bioenergetics * biogenesis
    Kód oboru RIV: ED - Fyziologie
    Impakt faktor: 4.887, rok: 2009

    We determined bioenergetic profiles of human fibroplasts taken from lung epidermoid carcinoma and fetal lung. We also analyzed human lung tumors and their surrounding healthy tissue from our pacients with adenocarcinoma. Results demonstrate that both the lung fetal and cancer cell lines produced their ATP predominantly by glycolysis, while oxidative phosphorylation was only capable of poor ATP delivery. A consistent reduction of mitochondrial biogenesis and the subsequent alteration of respiratory capacity was also observed in lung tumors, associated with lower expression level of bcl2
    Trvalý link: http://hdl.handle.net/11104/0182938