Počet záznamů: 1

Peroxidative damage of mitochondrial respiration is substrate-dependent

  1. 1.
    0338968 - FGU-C 2010 RIV CZ eng J - Článek v odborném periodiku
    Endlicher, R. - Křiváková, P. - Rauchová, Hana - Nůsková, Hana - Červinková, Z. - Drahota, Zdeněk
    Peroxidative damage of mitochondrial respiration is substrate-dependent.
    Physiological Research. Roč. 58, č. 5 (2009), s. 685-692 ISSN 0862-8408
    Grant CEP: GA ČR(CZ) GA303/06/1261
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: mitochondrial enzymes * peroxidative damage * tert-butyl hydroperoxide
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 1.430, rok: 2009

    The concentration-dependence of tert-butyl hydroperoxide (BHP) inhibitory effect on oxygen consumption in isolated rat liver mitochondria was measured in the presence of various respiratory substrates. Strong inhibitory effect at low concentrations of BHP (15-30 µM) was found for oxoglutarate and palmitoyl carnitine oxidation. Our data indicate that beside peroxidative damage of complex I also various mitochondrial NADH-dependent dehydrogenases are inhibited but to a different extent and with different kinetics. Our data also show that succinate could be an important nutritional substrate protecting hepatocytes during peroxidative damage
    Trvalý link: http://hdl.handle.net/11104/0182609