Počet záznamů: 1
The DNA-damage response in human biology and disease
0337838 - UMG-J 2010 RIV GB eng J - Článek v odborném periodiku
Jackson, S.P. - Bartek, Jiří
The DNA-damage response in human biology and disease.
Nature. Roč. 461, č. 7267 (2009), s. 1071-1078 ISSN 0028-0836
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: DNA damage response * human disease * cancer
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 34.480, rok: 2009
The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.
Trvalý link: http://hdl.handle.net/11104/0181743