Počet záznamů: 1

In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives

  1. 1.
    0337442 - UOCHB-X 2010 RIV US eng J - Článek v odborném periodiku
    Evangelou, A. - Zikos, C. - Benaki, D. - Pelecanou, M. - Bouziotis, P. - Papadopoulos, M. - Borovičková, Lenka - Veselá, Iva - Elbert, Tomáš - Kunešová, G. - Pirmettis, I. - Paravatou-Petsotas, M. - Slaninová, Jiřina - Livaniou, E.
    In vitro binding and in vivo biodistribution studies of the neuroprotective peptide humanin using [125I]humanin derivatives.
    Peptides. Roč. 30, č. 12 (2009), s. 2409-2417 ISSN 0196-9781
    Grant CEP: GA MŠk ME 872
    Grant ostatní: Czech-Greek Joint Research and Technology Programme(GR) 188-gamma
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: neuroprotective peptides * humanin derivatives * [125I] radiolabeling
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.705, rok: 2009

    Four new, tyrosine containing humanin derivatives were synthesized, the neuroprotective action was evaluated in the T-maze test and the most active ones were radiolabeled with 125I. Under the experimental conditions used, our data do not confirm the existence of specific binding sites for humanin on the neuronal tissue.
    Trvalý link: http://hdl.handle.net/11104/0181434