Počet záznamů: 1

Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts

  1. 1.
    0335551 - UMG-J 2010 RIV SG eng J - Článek v odborném periodiku
    Bakri, M.M. - Sutherland, A.D. - Brown, D.J. - Veselý, Pavel - Crossan, C. - Scobie, L.
    Assessment of the potential risk of infection associated with Clostridium difficile from porcine xenografts.
    Xenotransplantation. Roč. 16, č. 6 (2009), s. 472-476 ISSN 0908-665X
    Grant ostatní: EC(XE) LSHB-CT-2006-037377
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: C. difficile * hospital acquired infection * xenotransplant * zoonoses
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.711, rok: 2009

    There are numerous concerns over the potential transfer of pathogens between species during clinical xenotransplantation. Porcine xenografts have been previously used to treat patients with severe burns. As pigs are a known source of zoonotic agents, many diseases must be excluded from pigs used for xenotransplantation. Clostridium difficile is a major cause of neonatal enteritis in pigs, with an important feature that pigs can be its asymptomatic carriers. We examined the incidence of C. difficile PCR ribotypes present in healthy donor pigs to determine if pig faeces, and in particular contamination of skin with faeces, is a potential route for the transfer of C. difficile. Animals were found to have human ribotype 017 present in the faecal matter, but no C. difficile was isolated from skin samples taken from the same animals. Also, due to the risk factors associated with C. difficile infection, the antimicrobial susceptibility of the C. difficile isolates has been determined.
    Trvalý link: http://hdl.handle.net/11104/0179985