Počet záznamů: 1

Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water

  1. 1.
    0335375 - UFCH-W 2011 RIV CH eng J - Článek v odborném periodiku
    Gál, Miroslav - Hromadová, Magdaléna - Pospíšil, Lubomír - Híveš, J. - Sokolová, Romana - Kolivoška, Viliam - Kocábová, Jana
    Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water.
    Bioelectrochemistry. Roč. 78, č. 2 (2010), s. 118-123 ISSN 1567-5394
    Grant CEP: GA ČR GP203/09/P502
    Výzkumný záměr: CEZ:AV0Z40400503
    Klíčová slova: etanidazole * radiosensitizer * electron transfer * voltammetry
    Kód oboru RIV: CG - Elektrochemie
    Impakt faktor: 3.520, rok: 2010

    Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN − NO2 + e− right arrow over left arrow ETN − NO2•− was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined.
    Trvalý link: http://hdl.handle.net/11104/0179856