Počet záznamů: 1
Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks
0334910 - BC-A 2010 RIV DE eng J - Článek v odborném periodiku
Horká, Helena - Černá-Kýčková, Kateřina - Skallová, Anna - Kopecký, Jan
Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks.
International Journal of Medical Microbiology. Roč. 299, č. 5 (2009), s. 373-380 ISSN 1438-4221
Grant CEP: GA AV ČR IAA600960811; GA MŠk(CZ) LC06009
Výzkumný záměr: CEZ:AV0Z60220518
Klíčová slova: Borrelia burgdorferi * Ixodes ricinus * saliva-activated transmission * real-time PCR
Kód oboru RIV: EC - Imunologie
Impakt faktor: 2.802, rok: 2009
The influence of the feeding of uninfected Ixodes ricinus nymphs on the proliferation and distribution of Borrelia burgdorferi spirochetes was compared with the effect of coinoculated saliva or salivary gland extract (SGE). SGE significantly increased spirochete numbers in the skin 4 and 6 dpi, but decreased bacterial load in the heart compared to control animals. The inoculation of tick saliva increased spirochete load in the urinary bladder 6 dpi, while the number of spirochetes in the heart declined. The nymph feeding raised spirochete load in the bladder 4 and 6 dpi. On day 6, the number of spirochetes in the heart was significantly lower than in controls. The prevalence of spirochetes in ticks infected by feeding on mice was 10× higher when the mice were infected with spirochetes and saliva or SGE, in comparison with spirochetes alone. The presence of SGE in the inoculum increased spirochete burden per tick from 0 to almost 28000.
Trvalý link: http://hdl.handle.net/11104/0179519