Počet záznamů: 1

Tick-borne encephalitis virus infection of cultured mouse macrophages

  1. 1.
    0334900 - BC-A 2010 RIV SZ eng J - Článek v odborném periodiku
    Ahantarig, A. - Růžek, Daniel - Vancová, Marie - Janowitz, A. - Šťastná, Hana - Tesařová, Martina - Grubhoffer, Libor
    Tick-borne encephalitis virus infection of cultured mouse macrophages.
    Intervirology. Roč. 52, č. 5 (2009), s. 283-290 ISSN 0300-5526
    Grant CEP: GA ČR GA524/06/1479; GA MŠk(CZ) LC06009
    Výzkumný záměr: CEZ:AV0Z60220518
    Klíčová slova: tick-borne encephalitis * macrophages * electron microscopy
    Kód oboru RIV: GJ - Choroby a škůdci zvířat, veterinární medicína
    Impakt faktor: 1.106, rok: 2009

    The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratory mice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.
    Trvalý link: http://hdl.handle.net/11104/0179509