Počet záznamů: 1

The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects

  1. 1.
    0334798 - MBU-M 2010 RIV GB eng J - Článek v odborném periodiku
    Lorenz, N. - Haarmann, T. - Pažoutová, Sylvie - Jung, M. - Tudzynski, P.
    The ergot alkaloid gene cluster: Functional analyses and evolutionary aspects.
    Phytochemistry. Roč. 70, 15-16 (2009), s. 1822-1832 ISSN 0031-9422
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Claviceps purpurea * Ergot fungus * Ergot alkaloid gene cluster
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Impakt faktor: 3.104, rok: 2009

    Ergot alkaloids and their derivatives have been traditionally used as therapeutic agents in migraine, blood pressure regulation and help in childbirth and abortion. Their production in submerse culture is a long established biotechnological process. Ergot alkaloids are produced mainly by members of the genus Claviceps, with Claviceps purpurea as best investigated species concerning the biochemistry of ergot alkaloid synthesis (EAS). Genes encoding enzymes involved in EAS have been shown to be clustered; functional analyses of EAS cluster genes have allowed to assign specific functions to several gene products. Various Claviceps species differ with respect to their host specificity and their alkaloid content; comparison of the ergot alkaloid clusters in these species (and of clavine alkaloid clusters in other genera) yields interesting insights into the evolution of cluster structure
    Trvalý link: http://hdl.handle.net/11104/0179430