Počet záznamů: 1

Cytokine expression and signaling in drug-induced cellular senescence

  1. 1.
    0333900 - UMG-J 2010 RIV GB eng J - Článek v odborném periodiku
    Nováková, Zora - Hubáčková, Soňa - Košař, Martin - Janderová-Rossmeislová, Lenka - Dobrovolná, Jana - Vašicová, Pavla - Vančurová, Markéta - Hořejší, Zuzana - Hozák, Pavel - Bartek, Jiří - Hodný, Zdeněk
    Cytokine expression and signaling in drug-induced cellular senescence.
    Oncogene. Roč. 29, č. 2 (2010), s. 273-284 ISSN 0950-9232
    Grant CEP: GA AV ČR IAA500390501; GA ČR GA204/08/1418; GA MŠk LC545
    Grant ostatní: EC(XE) TRIREME
    Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50200510
    Klíčová slova: cellular senescence * cytokines * JAK/STAT signaling pathway
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 7.414, rok: 2010

    Cellular senescence, the permanent state of cell-cycle arrest, is emerging as an intrinsic barrier against tumorigenesis and a mechanism contributing to organismal ageing. Pathophysiologically relevant part of senescent phenotype is the expression and secretion of several cytokines. In this article we present that premature cellular senescence promoted by senescence-inducing compounds (e.g. bromodeoxyuridine, distamycin A, hydroxyurea, and aphidicoline) in several human tumor cell lines is accompanied by persistent activity of the interferon JAK/STAT signaling pathway and the expression of several interferon-stimulated genes such as MX1, OAS, ISG15, STAT1, PML, IRF1 and IRF7. JAK1/STAT-activating ligands IL-10, IL-20, IL-24, IFNgamma, IFNbeta and IL-6 were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT. Furthermore, cytokine genes including proinflammatory IL-1, TNF and TGF families were highly expressed.
    Trvalý link: http://hdl.handle.net/11104/0178775
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