Počet záznamů: 1

Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS

  1. 1.
    0332235 - UEM-P 2010 RIV US eng J - Článek v odborném periodiku
    Herynek, V. - Růžičková, Kateřina - Jendelová, Pavla - Syková, Eva - Hájek, M.
    Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS.
    Magnetic Resonance Materials in Physics, Biology and Medicine. Roč. 22, č. 4 (2009), s. 211-220 ISSN 0968-5243
    Grant CEP: GA AV ČR KAN201110651; GA MŠk(CZ) LC554; GA ČR(CZ) GA309/06/1594
    Grant ostatní: GA MŠk(CZ) 1M0538; EC-FP6 project DiMI(XE) LSHB-CT-2005-512146; GA MZd(CZ) MZ01IKEM2005
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: mesenchymal stem cell transplantation * magnetic resonance spectroscopy * rats
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 1.859, rok: 2009

    The article describes the metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation. 1H MRS revealed a gradual recovery of the damaged tissue; however, we found no significant differences in metabolite concentrations in the lesioned hemisphere between treated and untreated animals. Higher concentrations of glutamate and N-acetyl aspartate were found in the contralateral hemisphere in cell-treated animals compared to untreated ones. Lesioned animals showed neurogenesis in the contralateral hemisphere; the number of newly generated cells in stem cell-treated animals was 50% higher than that observed in untreated animals.
    Trvalý link: http://hdl.handle.net/11104/0177553