Počet záznamů: 1
Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS
0332235 - UEM-P 2010 RIV US eng J - Článek v odborném periodiku
Herynek, V. - Růžičková, Kateřina - Jendelová, Pavla - Syková, Eva - Hájek, M.
Metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation assessed by 1H MRS.
Magnetic Resonance Materials in Physics, Biology and Medicine. Roč. 22, č. 4 (2009), s. 211-220 ISSN 0968-5243
Grant CEP: GA AV ČR KAN201110651; GA MŠk(CZ) LC554; GA ČR(CZ) GA309/06/1594
Grant ostatní:GA MŠk(CZ) 1M0538; EC-FP6 project DiMI(XE) LSHB-CT-2005-512146; GA MZd(CZ) MZ01IKEM2005
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: mesenchymal stem cell transplantation * magnetic resonance spectroscopy * rats
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 1.859, rok: 2009
The article describes the metabolic changes in the rat brain after a photochemical lesion treated by stem cell transplantation. 1H MRS revealed a gradual recovery of the damaged tissue; however, we found no significant differences in metabolite concentrations in the lesioned hemisphere between treated and untreated animals. Higher concentrations of glutamate and N-acetyl aspartate were found in the contralateral hemisphere in cell-treated animals compared to untreated ones. Lesioned animals showed neurogenesis in the contralateral hemisphere; the number of newly generated cells in stem cell-treated animals was 50% higher than that observed in untreated animals.
Trvalý link: http://hdl.handle.net/11104/0177553