Počet záznamů: 1

Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir

  1. 1.
    0330753 - UOCHB-X 2010 RIV US eng J - Článek v odborném periodiku
    Grantz Šašková, Klára - Kožíšek, Milan - Řezáčová, Pavlína - Brynda, Jiří - Yashina, T. - Kagan, R. M. - Konvalinka, Jan
    Molecular Characterization of Clinical Isolates of Human Immunodeficiency Virus Resistant to the Protease Inhibitor Darunavir.
    Journal of Virology. Roč. 83, č. 17 (2009), s. 8810-8818 ISSN 0022-538X
    Grant CEP: GA MŠk 1M0508
    GRANT EU: European Commission(XE) 37693 - HIV PI RESISTANCE
    Výzkumný záměr: CEZ:AV0Z40550506; CEZ:AV0Z50520514
    Klíčová slova: HIV-1 protease * darunavir * X-ray structural analysis * protease inhibitor * mutations
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 5.150, rok: 2009

    In this work we report structural and enzymological analysis of a panel of clinically derived mutant HIV-1 proteases with high levels of phenotypic resistance to darunavir. Recombinant virus phenotypic characterization, enzyme kinetics, and X-ray structural analysis are used to explain darunavir resistance development in HIV-positive patiens.
    Trvalý link: http://hdl.handle.net/11104/0176467