Počet záznamů: 1

Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor

  1. 1.
    0330473 - UEM-P 2010 RIV NL eng J - Článek v odborném periodiku
    Valovičová, Z. - Marvanová, S. - Mészárosová, M. - Strančíková, A. - Trilecová, L. - Milcová, Alena - Líbalová, Helena - Vondráček, J. - Machala, M. - Topinka, Jan - Gábelová, A.
    Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor.
    Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 665, 1-2 (2009), s. 51-60 ISSN 0027-5107
    Grant CEP: GA MŠk 2B08005; GA MŽP(CZ) SP/1B3/8/08
    Výzkumný záměr: CEZ:AV0Z50390512
    Klíčová slova: DNA adducts * DNA strand breaks * oxidative stress
    Kód oboru RIV: DN - Vliv životního prostředí na zdraví
    Impakt faktor: 3.556, rok: 2009

    The qualitative differences in the DNA damage profiles produced by hepatocarcinogens DBC and DiMeDBC in WB-F344 cells were demonstrated. Different lesions may trigger distinct cellular pathways involved in hepatocarcinogenesis. The low amount of DNA damage, together with an efficient repair, may explain the lack of hepatocarcinogenicity of N-MeDBC.
    Trvalý link: http://hdl.handle.net/11104/0176256