Počet záznamů: 1

Porcine neuronal models that recapitulate HD pathogenesis in vitro

  1. 1.
    0329308 - UZFG-Y 2010 RIV IT eng C - Konferenční příspěvek (zahraniční konf.)
    Hruška-Plocháň, Marian - Vodička, Petr - Lacková, Monika - Usvald, Dušan - Juhás, Štefan - Hrdličková, R. - Miyanohara, A. - Maršala, M. - Motlík, Jan
    Porcine neuronal models that recapitulate HD pathogenesis in vitro.
    IV. Meeting on the molecular mechanisms of neurodegeneration. Vol. P 50. Milano: Keyword Europa, 2009, s. 32-32.
    [IV. Meeting on the molecular mechanisms of neurodegeneration. Miláno (IT), 08.05.2009-10.05.2009]
    Grant CEP: GA MŠk 1M0506
    Výzkumný záměr: CEZ:AV0Z50450515
    Klíčová slova: Huntington disease * porcine neuronal model
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

    Huntington disease is a fatal dominantly inherited neurodegenerative disease caused by the expansion of polyCAG stretch in gene coding ubiquitous huntingtin protein(htt). Selectively striatal neuronal loss followed by degemeration of cortex and other brain and non. neuronal regions occur in HD, but the function of mutated htt is not yet fully defined. The aim of this study is to develop porcine in vitro neuronal model that recapitulates major pathogenic steps in HD and would be much easily accessible than human cells and much closer to those primate origin that the rodent one
    Trvalý link: http://hdl.handle.net/11104/0175380