Počet záznamů: 1

Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period

  1. 1.
    0328977 - FGU-C 2010 RIV US eng J - Článek v odborném periodiku
    Walton, K. M. - Fisher, K. - Rubitski, D. - Marconi, M. - Meng, Q.-J. - Sládek, Martin - Adams, J. - Bass, M. - Chandrasekaran, R. - Butler, T. - Griffor, M. - Rajamohan, F. - Serpa, M. - Chen, Y. - Claffey, M. - Hastings, M. - Loudon, A. - Maywood, E. - Ohren, J. - Doran, A. - Wager, T. T.
    Selective Inhibition of Casein Kinase 1 epsilon Minimally Alters Circadian Clock Period.
    Journal of Pharmacology and Experimental Therapeutics. Roč. 330, č. 2 (2009), s. 430-439 ISSN 0022-3565
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: circadian clock * casein kinase 1 epsilon * inhibitor
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.093, rok: 2009

    Casein kinases 1 (CK1) epsilon and delta mutations have dramatic effect on circadian clock period. We have previously shown, that pan-CK1delta/epsilon inhibitor causes a delay in animal models of circadian rhythm, however it remains unclear, whether one of the kinases has predominant role. Here we have used novel selective CK1 epsilon inhibitor to show that wild-type CK1 epsilonhas only minimal effect on circadian clock relative to CK1 delta
    Trvalý link: http://hdl.handle.net/11104/0175143