Počet záznamů: 1

Analysis of Energy Stabilization inside the Hydrophobic Core of Rubredoxin

  1. 1.
    0327972 - UOCHB-X 2010 RIV DE eng J - Článek v odborném periodiku
    Berka, Karel - Hobza, Pavel - Vondrášek, Jiří
    Analysis of Energy Stabilization inside the Hydrophobic Core of Rubredoxin.
    ChemPhysChem. Roč. 10, č. 3 (2009), s. 543-548 ISSN 1439-4235
    Grant CEP: GA ČR GA203/05/0009; GA ČR GA203/06/1727; GA ČR(CZ) GD203/05/H001; GA AV ČR IAA400550510; GA MŠk LC512
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: hydrophobic core * protein stability * SAPT method
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Impakt faktor: 3.453, rok: 2009

    The hydrophobic core of globular proteins is responsible for major stabilization of the protein tertiary structure. The prevailing amino-acid residues in the core are of aliphatic or aromatic character, and therefore, the core in a folded protein structure is mostly stabilized by noncovalent interactions of van der Waals origin between the amino-acid side chains. Herein, we present a theoretical analysis of the interaction energy between the amino acids of the hydrophobic core of the small globular protein rubredoxin (Rd) based on the symmetry-adapted perturbation theory (SAPT) method.
    Trvalý link: http://hdl.handle.net/11104/0174393