Počet záznamů: 1

Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats

  1. 1.
    0327874 - FGU-C 2010 RIV NL eng J - Článek v odborném periodiku
    Folbergrová, Jaroslava - Druga, Rastislav - Tsenov, Grygoriy - Haugvicová, Renata - Otáhal, Jakub
    Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats.
    Brain Research. Roč. 1273, - (2009), s. 144-154 ISSN 0006-8993
    Grant CEP: GA ČR(CZ) GA309/05/2015; GA ČR GA309/08/0292; GA ČR(CZ) GA304/07/1137
    Výzkumný záměr: CEZ:AV0Z50110509; CEZ:AV0Z50200510
    Klíčová slova: DL-homocysteic acid-induced seizures * posttreatment with 2R * 4R-APDC * partial protection
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.463, rok: 2009

    Anticonvulsant and neuroprotective effect of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate, agonist for group II metabotropic glutamate receptors, was substantially reduced when given after the onset of seizures induced in immature rats by homocysteic acid. The severity of seizures, changes of brain energy metabolites and neuronal damage of hippocampus and thalamus were influenced only partially
    Trvalý link: http://hdl.handle.net/11104/0174325