Počet záznamů: 1

Efficient synthesis of phosphonodepsipeptides derived from norleucine

  1. 1.
    0327520 - UOCHB-X 2010 RIV GB eng J - Článek v odborném periodiku
    Pícha, Jan - Buděšínský, Miloš - Hančlová, Ivona - Šanda, Miloslav - Fiedler, Pavel - Vaněk, Václav - Jiráček, Jiří
    Efficient synthesis of phosphonodepsipeptides derived from norleucine.
    Tetrahedron. Roč. 65, č. 31 (2009), s. 6090-6103 ISSN 0040-4020
    Grant CEP: GA ČR GA203/06/1405; GA MŠk(CZ) LC06077
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: phosphonate * pseudopeptide * inhibitor * synthesis * norleucine
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.219, rok: 2009

    In the present work, we describe synthesis of phosphonopeptides mimicking the peptide sequences Nle-Gly(Ala) and Nle-Gly(Ala)-Val. The synthesis was achieved through BOP-catalysed coupling of the monobenzyl ester of the N-Cbz-protected phosphonate derivative of norleucine with the hydroxyl moieties of derivatised L-lactic or glycolic acid. Subsequently, complete deprotection of the products was achieved in good yields by one-step Pd-catalysed hydrogenolysis.
    Trvalý link: http://hdl.handle.net/11104/0174312