Počet záznamů: 1

Knockdown of proteins involved in iron metabolism limits tick reproduction and development

  1. 1.
    0327046 - BC-A 2010 RIV US eng J - Článek v odborném periodiku
    Hajdušek, O. - Sojka, Daniel - Kopáček, Petr - Burešová, Veronika - Franta, Zdeněk - Šauman, Ivo - Winzerling, J. - Grubhoffer, L.
    Knockdown of proteins involved in iron metabolism limits tick reproduction and development.
    Proceedings of the National Academy of Sciences of the United States of America. Roč. 106, č. 4 (2009), s. 1033-1038 ISSN 0027-8424
    Grant CEP: GA MŠk(CZ) LC06009; GA MŠk LC07032; GA AV ČR IAA600220603
    Výzkumný záměr: CEZ:AV0Z60220518; CEZ:AV0Z50070508
    Klíčová slova: tick ferritin * iron metabolism * RNA interference
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 9.432, rok: 2009

    We have characterized a new secreted ferritin (Fer2) and an iron regulatory protein (IRP1) from the hard tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (Fer1). Using RNA interference, we have proved that Fer2 plays a role as a transporter of non-heme iron from the tick gut to the periheral tissues. Knockdown of Fer2 dramatically impairs the ability of ticks to feed, thus making Fer2 a promising candidate for development of an efficient anti-tick vaccine.
    Trvalý link: http://hdl.handle.net/11104/0173951