Počet záznamů: 1

Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines

  1. 1.
    0326296 - UOCHB-X 2010 RIV FR eng J - Článek v odborném periodiku
    Doláková, Petra - Dračínský, Martin - Masojídková, Milena - Šolínová, Veronika - Kašička, Václav - Holý, Antonín
    Acyclic nucleoside bisphosphonates: Synthesis and properties of chiral 2-amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines.
    European Journal of Medicinal Chemistry. Roč. 44, č. 6 (2009), s. 2408-2424 ISSN 0223-5234
    Grant CEP: GA MŠk 1M0508
    Grant ostatní: NIH(US) 1UC1AIO62540-01
    Výzkumný záměr: CEZ:AV0Z40550506
    Klíčová slova: acyclic nucleoside phosphonates * pyrimidine * bisphosphonates
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 3.269, rok: 2009

    2-Amino-4,6-bis[(phosphonomethoxy)alkoxy]pyrimidines bearing two equal or different achiral or chiral phosphonoalkoxy chains have been prepared either by aromatic nucleophilic substitution of 2-amino-4,6-dichloropyrimidine or by alkylation of 4,6-dihydroxy-2-(methylsulfanyl)pyrimidine with appropriate phosphonate–bearing building block.
    Trvalý link: http://hdl.handle.net/11104/0173438