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pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy

SYSNO ASEP	0369686
Document Type	P - Patent
R&D Document Type	The record was not marked in the RIV
Title	pH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
Author(s)	Ulbrich, Karel (UMCH-V)_RID Etrych, Tomáš (UMCH-V)_{RID, ORCID} Říhová, Blanka (MBU-M)_RID Jelínková, Markéta (MBU-M) Kovář, Marek (MBU-M)_{RID, ORCID}
Year of issue	2011
Patent no. or utility model no. or industrial design no.	US7919076
Date of the patent acceptance	05.04.2011
Name of the patent owner	Zentiva, k. s
Language	eng - English
Country	US - United States
Keywords	cancerostatics ; polymer cojugates ; targeted therapy
Subject RIV	CC - Organic Chemistry
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
	AV0Z50200510 - MBU-M (2005-2011)
Annotation	Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated .alpha.-amino acids, .epsilon.-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2012

Number of the records: 1